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[21] Due to problems about the ability of JWH-018 and various manufactured cannabinoids to lead to psychosis in susceptible individuals, it has been proposed that persons with threat factors for insanity (such as a earlier or spouse and children background of psychosis) mustn't use these substances.
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It is actually changed at R1 by using a pentyl chain. The indole core is substituted at R3 with a carbonyl team which is also linked to a naphthalene moiety.